Sepsis is a life-threatening condition that arises when the body’s response to infection causes injury to its tissues and organs. If it’s incontinently treated it can lead to multiple organ failure and severe medical emergency. Our Kidneys are constantly affected by sepsis. This blog goes through the relationship between sepsis and kidney injury.
Sepsis occurs when the body’s vulnerable response to an infection becomes dysregulated, leading to uncontrol inflammation. Common causes of sepsis include bacterial, viral, and fungal infections. The immune system’s response to these infections can cause impairement of clotting function, thickning of blood vessels, and diminished blood flow, leading to damage to various organs.
The kidneys are highly susceptible to injury during sepsis due to their role in filtering blood and maintaining fluid and electrolyte balance. Sepsis-induced kidney injury, also known as sepsis-associated acute kidney injury(SA-AKI), occurs through several mechanisms:
Diagnosing Septic infection and AKI involves a combination of clinical evaluation and laboratory tests. The key diagnostic ways are:
Early and aggressive treatment is essential for managing septic infection and preventing kidney injury. Treatment strategies are as follows:
Preventing sepsis and kidney injury involves several strategies, They are:
Septic infection and Kidney Injury are closely linked, with each condition exacerbating the other. Understanding the signs, causes and treatments are crucial for managing these conditions effectively. If we are at risk, staying informed and seeking prompt medical attention can make a significant difference in outcomes.
6. Mukherjee, S., Bhaduri, S., Harwood, R. et al. Multiparametric MRI based assessment of kidney injury in a mouse model of ischemia reperfusion injury. Sci Rep 14, 19922 (2024). https://doi.org/10.1038/s41598-024-70401-x. https://doi.org/10.1038/s41598-024-70401-x
7. Acute kidney injury: prevention, detection and management (nice.org.uk)
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